Diagnostic Value of Nuclear Receptor Subfamily 4 Group A Member 3 in Salivary Gland Carcinomas

Salivary gland carcinomas are diagnostically challenging lesions in heterogeneous groups. However, recently described genomic alterations may be helpful and have future therapeutic implications. The molecular investigation is becoming useful tool to help diagnosis provide prognostic information. Diagnosis of acinic cell carcinoma (AcCC) due its rarity similarity with other SGCs or normal acinar cells.
 Herein, the diagnostic performance transcription factor nuclear receptor subfamily 4 group A member3 (NR4A3) was analysed immunohistochemically. This study done on 68 cases SCCs, including 32 AcCC, 14 adenoid cystic (AdCC), 8 mucoepidermoid (MEC), 7 epithelial myoepithelial (EMC), salivary duct (SDC), only one case from each ex pleomorphic adenoma (CXPA), polymorphous adenocarcinoma (PAC) secretory (SC) for detecting NR4A3.
 All stained samples AcCC (100%) responded positively NR4A3 antibody. AdCC MEC demonstrated immunostaining less than 10% cells. On hand, different types SGCs, EMC, SDC, CXPA, PAC, SC, revealed negative expressions. Therefore, we can conclude that used as a potential marker rather SGCs.